Mark Kopytman was born in 1929 in the former Soviet Union, where he received his early training in piano and music theory and later went on to study medicine. After graduating from medical school and while practicing medicine, Kopytman studied composition with Prof. R. Simovich at the Lvov Academy of Music and with Prof. S. Bogatirev at Tchaikovsky State Conservatoire in Moscow. After gaining his second PhD in 1958, Kopytman taught at the music academies of Moscow, Alma-Ata and Cisheneu. Several of his compositions (including the opera Casa Mare ) won prizes and distinctions in competitions and festivals

In 1972 Kopytman immigrated to Israel, where he was appointed Professor of Composition at the Rubin Academy of Music and Dance in Jerusalem, a position which combined compositional and pedagogical pursuits. Kopytman served as Chairman of the Theory and Composition Department, and later as Dean and the Deputy Head of the Academy (1974-1994).

Kopytman's compositional classes raised dozens of composers who gave gone to hold prominent positions as composers and teachers all over the world. In 1979, Kopytman was invited to teach as a permanent Guest Professor at Hebrew University. He has since led seminars and master classes in composition, especially in heterophony, a main focus of his creative world, at universities and music schools throughout Europe and the United States.

During 1982—1983 and 1988 –1989 Kopytman was a Visiting Professor at the University of Pennsylvania and in 1985, Composer in residence at Canberra school of Music (Australia). In 1991 he established the Doron Ensemble for the performance of the 20th century music. The year 1991 saw him as a judge at Gaudeamus Competition for Composers in Holland, while 1992 provided the opportunity to lecture at the Seminar for Young Composers in Kazimierz Dolny, Poland, and later in 1994, at the Chopin Academy of Music in Warsaw.

Since 1991 he lectured as Visiting Professor at the Tchaikovsky State Conservatoire in Moscow and 1995 he was invited to lead a seminar at the Brandenburg Colloquium for Contemporary Music (Berlin). In 1991 he was appointed as music adviser to the International Festival in St. Petersburg, and in 1992 –1993 he initiated the International Summer Courses and the International Composers Contest in Moldova. From 1992 he served as Composer in residence of the Israel Camerata Jerusalem. In 1998 he initiated and led the International Symposium "The Art of Composition – toward the 21st century" in Jerusalem.

During this period Kopytman developed a strong individual style, inspired by Jewish folklore and combined with economical use of recent innovations and characterized by a strong accent on melodic lines in the web of heterophonic splitting of textures. Numerous performances of his works have been held in the USSR, and later with increasing frequency, in Israel, Europe, the Unites States, South America, Canada, Japan, Korea, Australia, and most recently in the republics of the former USSR

His orchestral and chamber compositions have been performed at prestigious festivals, among them the Israel Festivals in 1975, 1976,1978 and 1979, the Testimonium 1983, the 1980, 1986 and 1997 World Music Days of ISCM, the Warsaw Autumn festivals of 1986, 1987 and 1989, the International Festival in Cologne (1989), The International Festival "Merzishor" in Moldova (1991, 1992), the "Musical Spring in St. Petersburg" (1991 –1993, 2000), the International Festivals in France (1993.1994), the Schlezwig Holstein festival (Germany,1994), Bartok World Music Days in Budapest (1999), the International Festival in Prague, "Wratislavia Cantans" in Poland (1995), Arthur Rubinstein Memorial Festival (Geneva, 1996), Biennale (Tel Aviv 1997), International Festivals in Geneva and Seoul (!997), Bohn (1999), Sofia (1999, 2000).

Kopytman is recipient of several prizes; among them the prestigious Koussevitzky International Record Critics award for his orchestral work Memory (1986), the Israel ACUM prize for his lifetime creative achievements (1992), and Israel Prime Minister Prize (2002).