Since 2003 Mr. Rose has also served as Music Director of Opera Boston, an innovative opera company in residence at the historic Cutler Majestic Theatre.  In 2007 Mr. Rose received Columbia University's prestigious Ditson Award and an ASCAP Concert Music Award for his exemplary commitment to new American music. In 2008 he was appointed Artistic Director of the inaugural Ditson Festival of Contemporary Music (Boston). Also in 2008 he launched BMOP/sound, the celebrated record label of the Boston Modern Orchestra Project.

As a guest conductor, Mr. Rose made his Tanglewood Festival debut in 2002 conducting Lukas Foss's opera Griffelkin, a work he recorded for Chandos and released in 2003 to rave reviews. In 2003 he made his guest debut with the Netherlands Radio Symphony conducting three world premieres as part of the Holland Festival. He has led the American Composers Orchestra, the Warsaw Philharmonic, the National Symphony Orchestra of the Ukraine, the Cleveland Chamber Symphony, the Orchestra della Swizzera Italia, and the National Orchestra of Porto, as well as several appearances with the Boston Symphony Chamber Players.

In June 2003, BMOP and Opera Boston together launched the much-celebrated Opera Unlimited, a ten-day contemporary opera festival featuring five operas and three world premieres. Mr. Rose led the world premiere of Elena Ruehr's Toussaint Before the Spirits, the New England premiere of Thomas Ades's Powder Her Face, as well as the revival of John Harbison's Full Moon in March with "skilled and committed direction" according to The Boston Globe. In 2006 the Opera Unlimited Festival presented the North American premiere of Peter Eötvös's Angels in America to critical acclaim.

Also recognized for interpreting standard operatic repertoire from Mozart to Bernstein, Mr. Rose's production of Verdi's Luisa Miller was hailed as an important operatic event. The Boston Globe recognized the production as "the best Verdi production presented in Boston in the last 15 years." Mr. Rose's recording of Samuel Barber's Vanessa for Naxos has been hailed as a significant achievement by the international press. He was chosen as the "Best Conductor of 2003" by Opera Online. He made his Chautauqua Opera debut in 2005 and in the 2007-08 season he led the Boston premiere of Osvaldo Golijov's Ainadamar with Dawn Upshaw and directed by Peter Sellars.

In addition to BMOP/sound, Gil Rose's recordings are available from BMOP/sound, Albany Records, Chandos, ECM, Naxos, New World Records, and Oxingale. His discography includes recordings of music by Samuel Barber, William Bolcom, Arthur Berger, Derek Bermel, Eric Chasalow, Shih-Hui Chen, Lukas Foss, Charles Fussell, Michael Gandolfi, John Harbison, Lee Hyla, David Lang, Tod Machover, Steven Mackey, Tigran Mansurian, Stephen Paulus, Bernard Rands, George Rochberg, Elena Ruehr, Gunther Schuller, Reza Vali, and Evan Ziporyn, among others. His recordings have been cited among the "Best CDs" of 2003, 2004, and 2008 by The New York Times, The Chicago Tribune, The Boston Globe, Time Out New York, Downbeat Magazine, and National Public Radoio, among others. His world premiere recording of Charles Fussell's Wilde, Symphony for baritone and orchestra received a 2009 Grammy Award nomination.